A Simple Synthesis Of New 2, 3-Dihydro-1H-1,5-Benzodiazepine Derivatives Using Symmetrical And Unsymmetrical Diamines

Abstract

Benzodiazepines are widely used drugs for several indications. This study provides, on the one hand, a global vision of this family starting for their fortuitous discovery, the synthesis of their derivatives, their mechanism of action which is well known nowadays, the actual classification according to the chemical structure and the pharmacokinetic properties and their uses and indications, including the traditional and the new ones. Synthesis of 2,3-dihydro-1H-1,5-benzodiazepine derivatives using symmetrical and unsymmetrical diamines and substituted ketones in presence of zirconium tetrachloride as a catalyst to obtain number of 1,5-benzodiazepine derivatives in very good yields.