New Protocol for Synthesis of Some Chalcones, Chromones and 1, 5 Benzothiazepines

Abstract

 2-Hydroxy acetophenones on treatment with 6-methyl-2-(1H-pyrazol-1-yl) quinoline-3-carbaldehyde and 4-(1H-pyrazol-1-yl) benzaldehyde by conventional and ultrasonication methods gave the corresponding chalcones. These chalcones were transformed into chromones and 1, 5-benzothizepines by using DMSO/I₂ and 2-aminothiophenol respectively. Compo­­unds  3h, 3j and 4j have shown better antibacterial activity against Gentamycin and Tetracycline. Similarly 4j have also been shown moderate antifungal activity against Ketoconazole taken as reference drug.