Ultrasound Promoted Synthesis and Characterization of Some Chalcones, Chromones and 1, 5 Benzothiazepines as Antibacterial and Antifungal Agents

Abstract

 2-Hydroxy acetophenones on treatment with 6-methyl-2-(1H-pyrazol-1-yl) quinoline-3-carbaldehyde  by conventional and ultrasonication methods gave the corresponding chalcones. These chalcones were transformed into chromones and 1, 5-benzothizepines by using DMSO/I₂ and 2-aminothiophenol respectively. Compounds 3b and 3e    have shown better antibacterial activity against Gentamycin and Tetracycline. Similarly 2e  have also been shown moderate antifungal activity against Ketoconazole taken as reference drug.