“Facile and Efficient One Pot Synthesis of Substituted Benzimidazoles under Ultrasonic Irradiation Using Novel Active 3% Cu-Doped Zinc Oxide Catalyst and Their Antimicrobial Activity ”

Abstract

Herein, we report for the first time, the synthesis of substituted  benzimidazoles through the coupling of Aromatic aldehydes with o-phenylenediamine by using recyclable, highly efficient and new  3% Cu-doped Zinc oxide catalyst in Ethanol  under ultrasound irradiation  and afforded high yields  (92-99 %) in a short period of time(10-20 min). Spectral data and Physical constant confirmed the formation of favored product. Antimicrobial activity of synthesized benzimidazoles compounds were checked and found extensively active against various gram positive , gram negative bacteria, yeast and some fungus. Simple methodology, short reaction times ,environmentally benign, mild reaction conditions with easy work-up procedure, inorganic low cost recyclable catalyst are the prominent features of this method. Great achievement of this work is to used catalyst atleast five to six times without losing its catalytic activity.